In 2025, the European Union Drugs Agency (EUDA) completed the project Synthetic Drugs 2050 to address increasing uncertainty surrounding the future production, distribution, and use of synthetic drugs in Europe up to 2050. Using horizon scanning, trend analysis, and sense-making approaches, the Foresight on Demand (FOD) project team and EUDA jointly developed four plausible scenarios to support EU-level and national stakeholders in anticipating emerging risks, identifying opportunities, and reinforcing the resilience of future policies.

The 2026 FOD–EUDA project marks the second phase of this foresight work and will focus on:

• Transforming the 2050 scenarios into interactive tools that foster strategic thinking
• Developing participatory formats that make complex foresight insights accessible and engaging
• Formulating recommendations for embedding foresight practices into EUDA’s strategic planning and policy development

The project will deliver:

• A Scenario Activation Toolkit with interactive resources
• Participatory testing and validation workshops with key stakeholders
• A final project report, including a toolkit manual and consolidated insights on the project’s outcomes
  

The European Union Drugs Agency’s (EUDA) project “Synthetic Drugs 2050” addressed the growing uncertainty surrounding the future availability, spread, and use of synthetic drugs in Europe up to 2050. Synthetic drugs represent a rapidly evolving and systemic challenge for Europe, affecting public health, security, social cohesion, productivity, and overall wellbeing. Accelerated technological change, globalised supply chains, digitalisation, and increasingly blurred boundaries between legal, illegal, controlled, and uncontrolled substances further amplify the complexity of this issue.

The project applied a participatory strategic foresight approach to explore possible futures of synthetic drugs in Europe, moving beyond short-term monitoring and reactive policy responses. By systematically analysing global and regional drivers of change, emerging trends, weak signals, and deep uncertainties, the project built a shared understanding of how synthetic drugs markets, uses, and impacts may evolve in the medium- and long-term.

Through horizon scanning, trend analysis, scenario building, and sense-making activities, Synthetic Drugs 2050 supports EU-level and national stakeholders in anticipating risks, identifying opportunities, and strengthening policy resilience. The project explicitly linked foresight insights to strategic reflection, policy options, and research priorities, while embedding capacity-building components to enhance futures literacy and long-term preparedness within the EU drug policy ecosystem.

Objectives

The Synthetic Drugs 2050 project encompassed:

• A comprehensive, methodologically robust foresight study on the future availability and use of synthetic drugs in Europe up to 2050, exploring systemic drivers, uncertainties, and disruptive developments across social, technological, economic, environmental, political, legal, and ethical dimensions.
• Development of multiple plausible future scenarios describing how synthetic drugs diffusion in Europe could evolve by 2050, challenging prevailing assumptions and highlighting non-obvious risks and opportunities.
• Mapping of first-, second-, and third-order implications of synthetic drugs diffusion across Europe, identifying cause–effect pathways, time-bound consequences, and cross-sectoral impacts on health, public safety, governance, and society.
• Support for strategic preparedness and policy resilience by co-developing policy responses, strategic options, and research and innovation priorities at EU and national levels.
• Further development of strengthened foresight capacity and futures literacy within EUDA and its stakeholder community through learning-by-doing, participatory engagement, and the development of reusable foresight tools and frameworks.

Outputs

• Horizon scanning and trend analysis reports
• A set of four future scenarios for synthetic drugs in Europe by 2050
• A mapped system of time-bound implications and cause–effect pathways
• Policy responses and strategic recommendations
• A foresight manual and horizon scanning framework for future use

Find more information here: https://www.euda.europa.eu/index_en